Recombinant Anti-B7H6 x Anti-CD3 Bispecific Antibody (Triple Body) (TRIB-017)

Recombinant Anti-B7H6 x Anti-CD3 Bispecific Antibody (Triple Body) is designed to be expressed as two polypeptide chains respectively. The Fd fragment and LC from an anti-B7H6 antibody are both extended with the scFv fragment from an anti-CD3 antibody. This BsAb can retarget T cells to tumor cells. It is designed for the research of Hematologic neoplasms; Solid tumors therapy.

Datasheet

Specifications

Targets

B7H6 & CD3

Type

Triple Body

Species Reactivity

Human

Target 1

B7H6

Host Animal 1

Mouse

Target 2

CD3

Host Animal 2

Mouse

Application

FuncS; Promising therapeutic agent

Related Disease

Hematologic neoplasms; Solid tumors

Targets

Target 1

B7H6

Gene ID

374383

UniProt ID

Q68D85

Alternative Names

NCR3LG1; natural killer cell cytotoxicity receptor 3 ligand 1; B7H6; B7-H6; DKFZp686O24166; natural cytotoxicity triggering receptor 3 ligand 1; B7 homolog 6; putative Ig-like domain-containing protein DKFZp686O24166/DKFZp686I21167

Target 2

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

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