Home > Products > BAFF & B7RP1 > Recombinant Human Anti-BAFF x Human Anti-B7RP1 Bispecific Antibody (Diabody-Fc)

Recombinant Human Anti-BAFF x Human Anti-B7RP1 Bispecific Antibody (Diabody-Fc)  (BSDBF-H198)

Recombinant Anti-BAFF x Anti-B7RP1 Bispecific Antibody (Diabody-Fc) is a fusion protein of two diabodies connected together by an Fc region. In a diabody, the two scFvs with short linkers are from anti-BAFF and anti-B7RP1 antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to the Fc fragment, which results in 2+2 antigen-binding valency and exerts Fc-mediated functions or just extends the half-life. This BsAb can bind and inactivate two ligands simultaneously. It can inhibit B cell survival and T cell costimulation. It is designed for the research of Systemic lupus erythematosus (SLE) therapy.

Specifications
Targets
BAFF & B7RP1
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
BAFF
Host Animal 1
Human
Target 2
B7RP1
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Systemic lupus erythematosus (SLE)
Targets
Target 1
BAFF
Gene ID
UniProt ID
Alternative Names
TNFSF13B; TNF superfamily member 13b; DTL; B cell activating factor; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF20
Target 2
B7RP1
Gene ID
UniProt ID
Alternative Names
ICOSLG; inducible T cell costimulator ligand; B7H2; GL50; B7-H2; B7­related protein; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L
Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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