Home > Products > BAFF & B7RP1 > Recombinant Anti-BAFF x Anti-B7RP1 Bispecific Antibody (F(ab')2-scFv2)

Recombinant Anti-BAFF x Anti-B7RP1 Bispecific Antibody (F(ab')2-scFv2)  (BABFV-H198)

Recombinant Anti-BAFF x Anti-B7RP1 Bispecific Antibody (F(ab')2-scFv2) is designed to be expressed as two chains combined via a hinge region. The scFv of the anti-BAFF specificity is fused to the C terminus of the anti-B7RP1 Fab fragment, or vice versa. This format comprises four binding sites (two same scFv regions and two same Fab fragments), two for each antigen. This BsAb can bind and inactivate two ligands simultaneously. It can inhibit B cell survival and T cell costimulation. It is designed for the research of Systemic lupus erythematosus (SLE) therapy.

Specifications
Targets
BAFF & B7RP1
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
BAFF
Host Animal 1
Human
Target 2
B7RP1
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Systemic lupus erythematosus (SLE)
Targets
Target 1
BAFF
Gene ID
UniProt ID
Alternative Names
TNFSF13B; TNF superfamily member 13b; DTL; B cell activating factor; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF20
Target 2
B7RP1
Gene ID
UniProt ID
Alternative Names
ICOSLG; inducible T cell costimulator ligand; B7H2; GL50; B7-H2; B7­related protein; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L

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