Home > Products > BAFF & B7RP1 > Recombinant Anti-BAFF x Anti-B7RP1 Bispecific Antibody (Fab-scFv-Fc)

Recombinant Anti-BAFF x Anti-B7RP1 Bispecific Antibody (Fab-scFv-Fc)  (FABVC-018)

Recombinant Anti-BAFF x Anti-B7RP1 Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-BAFF antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-B7RP1 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can bind and inactivate two ligands simultaneously. It can inhibit B cell survival and T cell costimulation. It is designed for the research of Systemic lupus erythematosus (SLE) therapy.

Specifications
Targets
BAFF & B7RP1
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
BAFF
Host Animal 1
Mouse
Target 2
B7RP1
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Systemic lupus erythematosus (SLE)
Targets
Target 1
BAFF
Gene ID
UniProt ID
Alternative Names
TNFSF13B; TNF superfamily member 13b; DTL; B cell activating factor; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF20
Target 2
B7RP1
Gene ID
UniProt ID
Alternative Names
ICOSLG; inducible T cell costimulator ligand; B7H2; GL50; B7-H2; B7­related protein; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L

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