Home > Products > BAFF & B7RP1 > Recombinant Anti-BAFF x Anti-B7RP1 Bispecific Antibody (Minibody)

Recombinant Anti-BAFF x Anti-B7RP1 Bispecific Antibody (Minibody)  (MiniB-018)

Recombinant Anti-BAFF x Anti-B7RP1 Bispecific Antibody (Minibody) is designed to be expressed as the anti-BAFF scFv fused to N-terminus of Knob-CH3 domain and the anti-B7RP1 scFv to the Hole-CH3 domain, or vice versa. The CH3 domains are further stabilized by C-terminal disulfide bonds. This BsAb can bind and inactivate two ligands simultaneously. It can inhibit B cell survival and T cell costimulation. It is designed for the research of Systemic lupus erythematosus (SLE) therapy.

Specifications
Targets
BAFF & B7RP1
Type
Minibody
Species Reactivity
Human
Target 1
BAFF
Host Animal 1
Mouse
Target 2
B7RP1
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Systemic lupus erythematosus (SLE)
Targets
Target 1
BAFF
Gene ID
UniProt ID
Alternative Names
TNFSF13B; TNF superfamily member 13b; DTL; B cell activating factor; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF20
Target 2
B7RP1
Gene ID
UniProt ID
Alternative Names
ICOSLG; inducible T cell costimulator ligand; B7H2; GL50; B7-H2; B7­related protein; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L
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