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Recombinant Anti-BAFF x Anti-IL17 Bispecific Antibody (F(ab')2-scFv2)  (BABFV-019)

Recombinant Anti-BAFF x Anti-IL17 Bispecific Antibody (F(ab')2-scFv2) is designed to be expressed as two chains combined via a hinge region. The scFv of the anti-BAFF specificity is fused to the C terminus of the anti-IL17 Fab fragment, or vice versa. This format comprises four binding sites (two same scFv regions and two same Fab fragments), two for each antigen. This BsAb can neutralize both BAFF and IL- 17 simultaneously. It is designed for the research of Lupus Nephritis (LN); Systemic Lupus Erythematosus (SLE); Rheumatoid Arthritis (RA); Psoriasis (Ps); Ankylosing Spondylitis (AS); Psoriatic Arthritis (PA) primary Sjögren's Syndrome (pSS); Multiple Myeloma (MM) therapy.

Specifications

Targets
BAFF & IL17
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
BAFF
Host Animal 1
Mouse
Target 2
IL17
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Lupus Nephritis (LN); Systemic Lupus Erythematosus (SLE); Rheumatoid Arthritis (RA); Psoriasis (Ps); Ankylosing Spondylitis (AS); Psoriatic Arthritis (PA) primary Sjögren's Syndrome (pSS); Multiple Myeloma (MM)

Targets

Target 1
BAFF
Gene ID
UniProt ID
Alternative Names
TNFSF13B; TNF superfamily member 13b; DTL; B cell activating factor; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF20
Target 2
IL17
Gene ID
UniProt ID
Alternative Names
IL17A; interleukin 17A; IL17; CTLA8; IL-17; IL-17A; interleukin-17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17

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