Home > Products > CA125 & HER2 > Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (Minibody)

Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (Minibody)  (MiniB-025)

Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (Minibody) is designed to be expressed as the anti-CA125 scFv fused to N-terminus of Knob-CH3 domain and the anti-HER2 scFv to the Hole-CH3 domain, or vice versa. The CH3 domains are further stabilized by C-terminal disulfide bonds. This BsAb can bind two factors simultaneously. It is designed for the research of Breast cancer; Gastric cancer; Prostate cacncer; Ovarian cancer; Solid tumors therapy.

Datasheet
Specifications
Targets
CA125 & HER2
Type
Minibody
Species Reactivity
Human
Target 1
CA125
Host Animal 1
Mouse
Target 2
HER2
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Breast cancer; Gastric cancer; Prostate cacncer; Ovarian cancer; Solid tumors
Targets
Target 1
CA125
Gene ID
94025
UniProt ID
Q8WXI7
Alternative Names
CA125; CA-125; cancer antigen 125; MUC16; mucin 16, cell surface associated
Target 2
HER2
Gene ID
2064
UniProt ID
P04626
Alternative Names
ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
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