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Recombinant Human Anti-CA19-9 x Human Anti-CD3 Bispecific Antibody (Diabody-Fc)  (CAT#: BSDBF-H203)

Recombinant Anti-CA19-9 x Anti-CD3 Bispecific Antibody (Diabody-Fc) is a fusion protein of two diabodies connected together by an Fc region. In a diabody, the two scFvs with short linkers are from anti-CA19-9 and anti-CD3 antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to the Fc fragment, which results in 2+2 antigen-binding valency and exerts Fc-mediated functions or just extends the half-life. This BsAb can retarget T cells to tumor cells. It is designed for the research of Ovarian cancer; Pancreatic cancer; Gastric cancer therapy.
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Specifications

Targets
CA19-9 & CD3
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Ovarian cancer; Pancreatic cancer; Gastric cancer

Targets

Target 1
CA19-9
Alternative Names
CA19-9; Cancer antigen 19-9; sialylated Lewis (a) antigen; Carbohydrate antigen 19-9
Target 2
CD3
Gene ID
UniProt ID
Alternative Names
CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.
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