Recombinant Anti-CA72-4 x Anti-CD3 Bispecific Antibody (Minibody) (MiniB-H204)

Recombinant Anti-CA72-4 x Anti-CD3 Bispecific Antibody (Minibody) is designed to be expressed as the anti-CA72-4 scFv fused to N-terminus of Knob-CH3 domain and the anti-CD3 scFv to the Hole-CH3 domain, or vice versa. The CH3 domains are further stabilized by C-terminal disulfide bonds. This BsAb can retarget T cells to tumor cells. It is designed for the research of Gastrointestinal cancer; Ovarian cancer; Colon cancer; Gastric cancer; Breast cancer; Adenocarcinomas therapy.

Datasheet

Specifications

Targets

CA72-4 & CD3

Type

Minibody

Species Reactivity

Human

Target 1

CA72-4

Host Animal 1

Human

Target 2

CD3

Host Animal 2

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Gastrointestinal cancer; Ovarian cancer; Colon cancer; Gastric cancer; Breast cancer; Adenocarcinomas

Targets

Target 1

CA72-4

Alternative Names

CA72-4; Cancer antigen 72-4; Carbohydrate antigen 72-4

Target 2

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

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