Home > Products > CCR3 & CD300 > Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Diabody-Fc)

Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Diabody-Fc)  (BSDBF-028)

Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Diabody-Fc) is a fusion protein of two diabodies connected together by an Fc region. In a diabody, the two scFvs with short linkers are from anti-CCR3 and anti-CD300 antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to the Fc fragment, which results in 2+2 antigen-binding valency and exerts Fc-mediated functions or just extends the half-life. This BsAb canreduce eosinophil signaling, inhibit bronchoalveolar lavage fluid inflammation, eosinophil, mast cell mediator release and reverse lung inflammation. It is designed for the research of Asthma therapy.

Specifications

Targets
CCR3 & CD300
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
CCR3
Host Animal 1
Mouse
Target 2
CD300
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Asthma

Targets

Target 1
CCR3
Gene ID
UniProt ID
Alternative Names
CCR3; C-C motif chemokine receptor 3; CKR3; CD193; CMKBR3; CC-CKR-3
Target 2
CD300
Gene ID
UniProt ID
Alternative Names
CD300A; CD300a molecule; IRC1; IRC2; CLM-8; IRp60; IGSF12; CMRF35H; CMRF-35H; CMRF35-H; CMRF35H9; CMRF35-H9; IRC1/IRC2; CMRF-35-H9

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