Recombinant Human Anti-CCR3 x Human Anti-CD300 Bispecific Antibody (F(ab')2-scFv2) (BABFV-H205)

Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (F(ab')2-scFv2) is designed to be expressed as two chains combined via a hinge region. The scFv of the anti-CCR3 specificity is fused to the C terminus of the anti-CD300 Fab fragment, or vice versa. This format comprises four binding sites (two same scFv regions and two same Fab fragments), two for each antigen. This BsAb canreduce eosinophil signaling, inhibit bronchoalveolar lavage fluid inflammation, eosinophil, mast cell mediator release and reverse lung inflammation. It is designed for the research of Asthma therapy.

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Specifications

Targets

CCR3 & CD300

Type

Fab-Fc Fusion Proteins

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Asthma

Targets

Target 1

CCR3

Gene ID

1232

UniProt ID

P51677

Alternative Names

CCR3; C-C motif chemokine receptor 3; CKR3; CD193; CMKBR3; CC-CKR-3

Target 2

CD300

Gene ID

11314

UniProt ID

Q9UGN4

Alternative Names

CD300A; CD300a molecule; IRC1; IRC2; CLM-8; IRp60; IGSF12; CMRF35H; CMRF-35H; CMRF35-H; CMRF35H9; CMRF35-H9; IRC1/IRC2; CMRF-35-H9

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-CCR3 x Human Anti-CD300 Bispecific Antibody (F(ab')2-scFv2) (CAT#: BABFV-H205)

Specifications

Targets

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