Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Fab-Fv) (FABFV-028)

Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Fab-Fv) is designed to be expressed as two polypeptide chains. The heavy chain Fd fragment and light chain of an anti-CCR3 antibody are fused with the VL and VH domains of an anti-CD300 antibody respectively. It can form natural in vivo heterodimerization. This BsAb canreduce eosinophil signaling, inhibit bronchoalveolar lavage fluid inflammation, eosinophil, mast cell mediator release and reverse lung inflammation. It is designed for the research of Asthma therapy.

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Specifications

Targets

CCR3 & CD300

Type

Fab-Fv

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Asthma

Targets

Target 1

CCR3

Gene ID

1232

UniProt ID

P51677

Alternative Names

CCR3; C-C motif chemokine receptor 3; CKR3; CD193; CMKBR3; CC-CKR-3

Target 2

CD300

Gene ID

11314

UniProt ID

Q9UGN4

Alternative Names

CD300A; CD300a molecule; IRC1; IRC2; CLM-8; IRp60; IGSF12; CMRF35H; CMRF-35H; CMRF35-H; CMRF35H9; CMRF35-H9; IRC1/IRC2; CMRF-35-H9

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Fab-Fv) (CAT#: FABFV-028)

Specifications

Targets

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