Home > Products > CCR3 & CD300 > Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Fv-IgG)

Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Fv-IgG)  (BSDG-028)

Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Fv-IgG) is an appended IgG format, which has 2+2 antigen-binding valency. This dual variable domain IgG is generated by appending variable domains of an anti-CCR3 IgG with similar domains from an anti-CD300 antibody via short peptide linkers, or vice versa. This BsAb canreduce eosinophil signaling, inhibit bronchoalveolar lavage fluid inflammation, eosinophil, mast cell mediator release and reverse lung inflammation. It is designed for the research of Asthma therapy.

Specifications

Targets
CCR3 & CD300
Type
Appended IgGs
Species Reactivity
Human
Target 1
CCR3
Host Animal 1
Mouse
Target 2
CD300
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Asthma

Targets

Target 1
CCR3
Gene ID
UniProt ID
Alternative Names
CCR3; C-C motif chemokine receptor 3; CKR3; CD193; CMKBR3; CC-CKR-3
Target 2
CD300
Gene ID
UniProt ID
Alternative Names
CD300A; CD300a molecule; IRC1; IRC2; CLM-8; IRp60; IGSF12; CMRF35H; CMRF-35H; CMRF35-H; CMRF35H9; CMRF35-H9; IRC1/IRC2; CMRF-35-H9

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