Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Tandem Fab) is designed to be expressed as three chains derived from the variable domains of anti-CCR3 and anti-CD300 parental antibodies. It contains a His-tag for affinity purification. And the two Fd regions are connected by a flexible linker. This BsAb canreduce eosinophil signaling, inhibit bronchoalveolar lavage fluid inflammation, eosinophil, mast cell mediator release and reverse lung inflammation. It is designed for the research of Asthma therapy.