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Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Tandem scFv-Fc)  (BSFVF-028)

Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Tandem scFv-Fc) is designed to be expressed as a homodimer, which has 2+2 antigen-binding valency. This format consists of one Fc region and two tandem scFv fragments, in which the anti-CCR3/CD300 tandem scFv is fused to the Fc domain. The engineered fragment format is used to extend the half-life. This BsAb canreduce eosinophil signaling, inhibit bronchoalveolar lavage fluid inflammation, eosinophil, mast cell mediator release and reverse lung inflammation. It is designed for the research of Asthma therapy.

Specifications

Targets
CCR3 & CD300
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
CCR3
Host Animal 1
Mouse
Target 2
CD300
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Asthma

Targets

Target 1
CCR3
Gene ID
UniProt ID
Alternative Names
CCR3; C-C motif chemokine receptor 3; CKR3; CD193; CMKBR3; CC-CKR-3
Target 2
CD300
Gene ID
UniProt ID
Alternative Names
CD300A; CD300a molecule; IRC1; IRC2; CLM-8; IRp60; IGSF12; CMRF35H; CMRF-35H; CMRF35-H; CMRF35H9; CMRF35-H9; IRC1/IRC2; CMRF-35-H9

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