Home > Products > CCR5 & CD3 > Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (Fab-scFv-Fc)

Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (Fab-scFv-Fc)  (FABVC-029)

Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CCR5 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-CD3 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can retarget T cells to CCR5 target cells. It is designed for the research of HIV-1 infection, AIDS therapy.

Specifications
Targets
CCR5 & CD3
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
CCR5
Host Animal 1
Mouse
Target 2
CD3
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
HIV-1 infection, AIDS
Targets
Target 1
CCR5
Gene ID
UniProt ID
Alternative Names
CCR5; C-C motif chemokine receptor 5; CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5
Target 2
CD3
Gene ID
UniProt ID
Alternative Names
CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

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