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Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (Miniantibody)  (MNAB-029)

Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (Miniantibody) is a fusion protein of two scFv fragments combined with distinct specificity. One scFv of an anti-CCR5 antibody variable domain is linked to another scFv of an anti-CD3 antibody variable domain by a flexible hinge region. This BsAb format has the decreased size and better penetration than conventional IgGs in the clinical diagnostics and potentially therapy. This BsAb can retarget T cells to CCR5 target cells. It is designed for the research of HIV-1 infection, AIDS therapy.

Specifications
Targets
CCR5 & CD3
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
CCR5
Host Animal 1
Mouse
Target 2
CD3
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
HIV-1 infection, AIDS
Targets
Target 1
CCR5
Gene ID
UniProt ID
Alternative Names
CCR5; C-C motif chemokine receptor 5; CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5
Target 2
CD3
Gene ID
UniProt ID
Alternative Names
CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
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