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Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (IgG(L)-scFv)  (CAT#: IGLFV-030)

Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (IgG(L)-scFv) is formed by an IgG and two scFv moieties. The scFv fragments from an anti-CD123 antibody are fused to the C terminus of an anti-CD3 IgG light (L) chains, or vice versa. It is a type of appended IgGs, which is bispecific and tetravalent (2+2 antigen-binding valency). This BsAb can retarget T cells to tumor cells. It is designed for the research of Acute myelogenous leukemia (AML); Chronic myelogenous leukemia (CML); Plasmacytoid leukemia therapy.
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Specifications

Targets
CD123 & CD3
Type
Appended IgGs
Species Reactivity
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Acute myelogenous leukemia (AML); Chronic myelogenous leukemia (CML); Plasmacytoid leukemia

Targets

Target 1
CD123
Gene ID
UniProt ID
Alternative Names
IL3RA; Cluster of differentiation 123; interleukin 3 receptor subunit alpha; IL3R; CD123; IL3RX; IL3RY; IL3RAY; hIL-3Ra
Target 2
CD3
Gene ID
UniProt ID
Alternative Names
CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.
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