Name: Recombinan Human Anti-CD123 x Human Anti-Vδ2 Bispecific Antibody (Fab-scFv-Fc)
SKU: KN-0825-N70
Rating: 5 (1 reviews)

Recombinan Human Anti-CD123 x Human Anti-Vδ2 Bispecific Antibody (Fab-scFv-Fc) is designed to be expressed as three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CD123 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-Vδ2 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can retarget γδ T cells to CD123+ tumor cells . It is designed for the research of Breast cancer; Gastric cancer; Prostate cacncer; Ovarian cancer; Solid tumors therapy.

Datasheet INQUIRY

Specifications

Targets

CD123 & Vδ2

Type

Fab-scFv/sdAb-Fc

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Acute myelogenous leukemia (AML); Chronic myelogenous leukemia (CML); Plasmacytoid leukemia

Host Animal 1

Human

Host Animal 2

Human

Targets

Target 1

CD123

Gene ID

3563

UniProt ID

P26951

Alternative Names

IL3RA; Cluster of differentiation 123; interleukin 3 receptor subunit alpha; IL3R; CD123; IL3RX; IL3RY; IL3RAY; hIL-3Ra

Target 2

Vδ2

Gene ID

28517

UniProt ID

A0JD36

Alternative Names

Vδ2+ T cells; Vγ9+Vδ2+ T cells; γδT cells; Vδ2 chain; Vδ2Vγ9+ T cells; TRDV2; T cell receptor delta variable 2; hDV102S1

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

Online Inquiry

See other bsAb targets related to "CD123"

See other bsAb targets related to "Vδ2"

Customer Reviews and Q&As

There are currently no customer reviews or questions for Recombinan Human Anti-CD123 x Human Anti-Vδ2 Bispecific Antibody (Fab-scFv-Fc) (KN-0825-N70). Click the button below to contact us or submit your feedback about this product.

Recombinan Human Anti-CD123 x Human Anti-Vδ2 Bispecific Antibody (Fab-scFv-Fc) (CAT#: KN-0825-N70)

Specifications

Targets

Customer Reviews and Q&As