Name: Recombinan Human Anti-CD123 x Human Anti-Vγ9 Bispecific Antibody (Fab-scFv-Fc)
SKU: KN-0825-N68
Rating: 5 (1 reviews)

Recombinan Human Anti-CD123 x Human Anti-Vγ9 Bispecific Antibody (Fab-scFv-Fc) is designed to be expressed as three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CD123 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-Vγ9 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can retarget γδ T cells to CD123+ tumor cells . It is designed for the research of Breast cancer; Gastric cancer; Prostate cacncer; Ovarian cancer; Solid tumors therapy.

Datasheet INQUIRY

Specifications

Targets

CD123 & Vγ9

Type

Fab-scFv/sdAb-Fc

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Acute myelogenous leukemia (AML); Chronic myelogenous leukemia (CML); Plasmacytoid leukemia

Host Animal 1

Human

Host Animal 2

Human

Targets

Target 1

CD123

Gene ID

3563

UniProt ID

P26951

Alternative Names

IL3RA; Cluster of differentiation 123; interleukin 3 receptor subunit alpha; IL3R; CD123; IL3RX; IL3RY; IL3RAY; hIL-3Ra

Target 2

Vγ9

Gene ID

6983

UniProt ID

Q99603

Alternative Names

Vgamma9Vdelta2; TCR γ-chain; γ9 subunit of Vγ9Vδ2 TCR complex; High-affinity Vγ9-containing TCR; TRGV9; T cell receptor gamma variable 9; V2; TRGC1; TCRGV9

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

Online Inquiry

See other bsAb targets related to "CD123"

See other bsAb targets related to "Vγ9"

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Recombinan Human Anti-CD123 x Human Anti-Vγ9 Bispecific Antibody (Fab-scFv-Fc) (CAT#: KN-0825-N68)

Specifications

Targets

Customer Reviews and Q&As