Home > Products > CD133 & EGFR > Recombinant Anti-CD133 x Anti-EGFR Bispecific Antibody (scDiabody-Fc)

Recombinant Anti-CD133 x Anti-EGFR Bispecific Antibody (scDiabody-Fc)  (CAT#: SCDBF-031)

Recombinant Anti-CD133 x Anti-EGFR Bispecific Antibody (scDiabody-Fc) is a fusion protein of two scDiabodies with an Fc region. In single-chain Diabodies, an additional connecting linker is introduced between chains of the anti-CD133/anti-EGFR diabody. The scDiabody with two specificities is further fused to the Fc domain to form BsAb with 2+2 antigen-binding valency. This BsAb can target brain tumor stem cells. It is designed for the research of Head and neck cancer; Colorectal cancer (CRC); Glioblastoma multiforme (GBM); Squamous cancer; Glioblastoma; Medulloblastoma; Non-small cell lung cancer (NSCLC); Renal cell cancer (RCC); Solid tumors therapy.
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Specifications

Targets
CD133 & EGFR
Type
scDiabody-Fc
Species Reactivity
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Head and neck cancer; Colorectal cancer (CRC); Glioblastoma multiforme (GBM); Squamous cancer; Glioblastoma; Medulloblastoma; Non-small cell lung cancer (NSCLC); Renal cell cancer (RCC); Solid tumors
Host Animal 1
Mouse
Host Animal 2
Mouse

Targets

Target 1
CD133
Gene ID
8842
UniProt ID
O43490
Alternative Names
PROM1; prominin 1; RP41; AC133; CD133; MCDR2; STGD4; CORD12; PROML1; MSTP061; prominin-1; hProminin; antigen AC133; prominin-like protein 1; hematopoietic stem cell antigen
Target 2
EGFR
Gene ID
1956
UniProt ID
P00533
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.
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