Home > Products > CD15 & CD64 > Recombinant Anti-CD15 x Anti-CD64 Bispecific Antibody (Diabody-CH3)

Recombinant Anti-CD15 x Anti-CD64 Bispecific Antibody (Diabody-CH3)  (BSDBC-032)

Recombinant Anti-CD15 x Anti-CD64 Bispecific Antibody (Diabody-CH3) is a fusion protein of two diabodies connected together by a CH3 region. In a diabody, the two scFvs with short linkers are from anti-CD15 and anti-CD64 antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to each of the CH3 chains, which results in 2+2 antigen-binding valency and extends the half-life of this BsAb. This BsAb can retarget neutrophils to tumor cells. It is designed for the research of Leukemia therapy.

Specifications

Targets
CD15 & CD64
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
CD15
Host Animal 1
Mouse
Target 2
CD64
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Leukemia

Targets

Target 1
CD15
Gene ID
UniProt ID
Alternative Names
FUT4; fucosyltransferase 4; LeX; CD15; ELFT; FCT3A; FUTIV; SSEA-1; FUC-TIV; 3-FAL; 3-fucosyl-N-acetyllactosamine; stage-specific embryonic antigen-1; Lewis X; X-hapten
Target 2
CD64
Gene ID
UniProt ID
Alternative Names
FCGR1A; Fc fragment of IgG receptor Ia; CD64; FCRI; CD64A; IGFR1; Cluster of Differentiation 64; FcγRI; FCGR1B; FCGR1C; immunoglobulin G Fc receptor high affinity I; Fc gamma RI

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