Home > Products > CD15 & CD64 > Recombinant Human Anti-CD15 x Human Anti-CD64 Bispecific Antibody (Fab-scFv-Fc)

Recombinant Human Anti-CD15 x Human Anti-CD64 Bispecific Antibody (Fab-scFv-Fc)  (FABVC-H209)

Recombinant Anti-CD15 x Anti-CD64 Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CD15 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-CD64 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can retarget neutrophils to tumor cells. It is designed for the research of Leukemia therapy.

Specifications
Targets
CD15 & CD64
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
CD15
Host Animal 1
Human
Target 2
CD64
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Leukemia
Targets
Target 1
CD15
Gene ID
UniProt ID
Alternative Names
FUT4; fucosyltransferase 4; LeX; CD15; ELFT; FCT3A; FUTIV; SSEA-1; FUC-TIV; 3-FAL; 3-fucosyl-N-acetyllactosamine; stage-specific embryonic antigen-1; Lewis X; X-hapten
Target 2
CD64
Gene ID
UniProt ID
Alternative Names
FCGR1A; Fc fragment of IgG receptor Ia; CD64; FCRI; CD64A; IGFR1; Cluster of Differentiation 64; FcγRI; FCGR1B; FCGR1C; immunoglobulin G Fc receptor high affinity I; Fc gamma RI
Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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