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Recombinant Human Anti-CD15 x Human Anti-DENV Bispecific Antibody (Fab-scFv-Fc)  (FABVC-H210)

Recombinant Anti-CD15 x Anti-DENV Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CD15 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-DENV to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb is designed for the research of antibody-dependent enhancement (ADE) and dengue virus infection.

Specifications

Targets
CD15 & DENV
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
CD15
Host Animal 1
Human
Target 2
DENV
Host Animal 2
Human
Application
FuncS
Related Disease
Dengue virus infection

Targets

Target 1
CD15
Gene ID
UniProt ID
Alternative Names
FUT4; fucosyltransferase 4; LeX; CD15; ELFT; FCT3A; FUTIV; SSEA-1; FUC-TIV; 3-FAL; 3-fucosyl-N-acetyllactosamine; stage-specific embryonic antigen-1; Lewis X; X-hapten
Target 2
DENV
Alternative Names
dengue virus; DENV; dengue fever; Flavivirus

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