Home > Products > CD16 & CD30 > Recombinant Human Anti-CD16 x Human Anti-CD30 Bispecific Antibody (Minibody)

Recombinant Human Anti-CD16 x Human Anti-CD30 Bispecific Antibody (Minibody)  (MiniB-H211)

Recombinant Anti-CD16 x Anti-CD30 Bispecific Antibody (Minibody) is designed to be expressed as the anti-CD16 scFv fused to N-terminus of Knob-CH3 domain and the anti-CD30 scFv to the Hole-CH3 domain, or vice versa. The CH3 domains are further stabilized by C-terminal disulfide bonds. This BsAb can retarget NK cells to tumor cells. It is designed for the research of Neuroblastoma; Osteosarcoma; Hodgkin lymphoma; T cell lymphoma; Anaplastic large cell lymphoma (ALCL) therapy.

Datasheet
Specifications
Targets
CD16 & CD30
Type
Minibody
Species Reactivity
Human
Target 1
CD16
Host Animal 1
Human
Target 2
CD30
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Neuroblastoma; Osteosarcoma; Hodgkin lymphoma; T cell lymphoma; Anaplastic large cell lymphoma (ALCL)
Targets
Target 1
CD16
Gene ID
2214
UniProt ID
M9MML0
Alternative Names
FCGR3A; Fc fragment of IgG, low affinity IIIa, receptor (CD16a); CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; FCGRIII; FCRIIIA; low affinity immunoglobulin gamma Fc region receptor III-A; FcγRIII; FcgammaRIIIA; CD16a antigen; fc-gamma RIII; Fc-gamma RIIIa; Fc-gamma RIII-alpha; igG Fc receptor III-2; Fc gamma receptor III-A; Fc-gamma receptor IIIb (CD16); neutrophil-specific antigen NA; Fc-gamma receptor III-2 (CD 16); immunoglobulin G Fc receptor III; Fc fragment of IgG, low affinity III, receptor for (CD16)
Target 2
CD30
Gene ID
943
UniProt ID
A5D8T4
Alternative Names
TNFRSF8; tumor necrosis factor receptor superfamily, member 8; CD30; Ki-1; D1S166E; tumor necrosis factor receptor superfamily member 8; Ki-1 antigen; CD30L receptor; cytokine receptor CD30; lymphocyte activation antigen CD30
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