Recombinant Anti-CD16 x Anti-CD30 Bispecific Antibody (Minibody) is designed to be expressed as the anti-CD16 scFv fused to N-terminus of Knob-CH3 domain and the anti-CD30 scFv to the Hole-CH3 domain, or vice versa. The CH3 domains are further stabilized by C-terminal disulfide bonds. This BsAb can retarget NK cells to tumor cells. It is designed for the research of Neuroblastoma; Osteosarcoma; Hodgkin lymphoma; T cell lymphoma; Anaplastic large cell lymphoma (ALCL) therapy.
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