Home > Products > CD19 & CD47 > Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Fab-scFv-Fc)

Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Fab-scFv-Fc)  (FABVC-042)

Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CD19 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-CD47 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can retarget macrophages to tumor cells. It is designed for the research of B cell lymphoma; Follicular lymphoma; Burkitt lymphoma; Leukemia therapy.

Specifications

Targets
CD19 & CD47
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
CD19
Host Animal 1
Mouse
Target 2
CD47
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
B cell lymphoma; Follicular lymphoma; Burkitt lymphoma; Leukemia

Targets

Target 1
CD19
Gene ID
UniProt ID
Alternative Names
CD19; CD19 molecule; Cluster of differentiation 19; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4
Target 2
CD47
Gene ID
UniProt ID
Alternative Names
CD47; CD47 molecule; IAP; OA3; MER6; leukocyte surface antigen CD47; CD47 glycoprotein; Rh-related antigen; integrin associated protein; integrin-associated protein; integrin-associated signal transducer; antigenic surface determinant protein OA3; antigen identified by monoclonal antibody 1D8; CD47 antigen (Rh-related antigen, integrin-associated signal transducer)

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