Home > Products > CD19 & CD59 > Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (scFv-IgG)

Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (scFv-IgG)  (BSSG-H220)

Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (scFv-IgG) is formed by an IgG and two scFv fragments. The scFvs from an anti-CD19 antibody variable domain are respectively connected to the N terminus of the anti-CD59 IgG heavy chains or light chains to form scFv-(H)IgG or scFv-(L)IgG. It is a type of appended IgGs and has 2+2 antigen-binding valency. This BsAb can recruit complement to tumor cells. It is designed for the research of B cell lymphoma; Leukemia therapy.

Specifications
Targets
CD19 & CD59
Type
Appended IgGs
Species Reactivity
Human
Target 1
CD19
Host Animal 1
Human
Target 2
CD59
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
B cell lymphoma; Leukemia
Targets
Target 1
CD19
Gene ID
UniProt ID
Alternative Names
CD19; CD19 molecule; Cluster of differentiation 19; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4
Target 2
CD59
Gene ID
UniProt ID
Alternative Names
CD59; CD59 molecule, complement regulatory protein; 1F5; EJ16; EJ30; EL32; G344; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; 16.3A5; HRF-20; MAC-IP; p18-20; CD59 glycoprotein; protectin; 1F5 antigen; MEM43 antigen; Ly-6-like protein; T cell-activating protein; human leukocyte antigen MIC11; lymphocytic antigen CD59/MEM43; 20 kDa homologous restriction factor; membrane inhibitor of reactive lysis; membrane attack complex inhibition factor; membrane attack complex (MAC) inhibition factor; surface anitgen recognized by monoclonal antibody 16.3A5; CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344)
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