Home > Products > CD20 & CD22 > Recombinant Anti-CD20 x Anti-CD22 Bispecific Antibody (Fab-scFv-Fc)

Recombinant Anti-CD20 x Anti-CD22 Bispecific Antibody (Fab-scFv-Fc)  (FABVC-049)

Recombinant Anti-CD20 x Anti-CD22 Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CD20 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-CD22 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb is designed for the research of Lymphoma; Leukemia; Antoimmune disease; Immune dysfunction disease therapy.

Specifications
Targets
CD20 & CD22
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
CD20
Host Animal 1
Mouse
Target 2
CD22
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Lymphoma; Leukemia; Antoimmune disease; Immune dysfunction disease
Targets
Target 1
CD20
Gene ID
UniProt ID
Alternative Names
MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16; B-lymphocyte antigen CD20; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1
Target 2
CD22
Gene ID
UniProt ID
Alternative Names
CD22; CD22 molecule; Cluster of differentiation 22; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2
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