Recombinant Anti-CD20 x Anti-CD22 Bispecific Antibody (Minibody) (MiniB-H226)

Recombinant Anti-CD20 x Anti-CD22 Bispecific Antibody (Minibody) is designed to be expressed as the anti-CD20 scFv fused to N-terminus of Knob-CH3 domain and the anti-CD22 scFv to the Hole-CH3 domain, or vice versa. The CH3 domains are further stabilized by C-terminal disulfide bonds. This BsAb is designed for the research of Lymphoma; Leukemia; Antoimmune disease; Immune dysfunction disease therapy.

Datasheet

Specifications

Targets

CD20 & CD22

Type

Minibody

Species Reactivity

Human

Target 1

CD20

Host Animal 1

Human

Target 2

CD22

Host Animal 2

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Lymphoma; Leukemia; Antoimmune disease; Immune dysfunction disease

Targets

Target 1

CD20

Gene ID

931

UniProt ID

A0A024R507

Alternative Names

MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16; B-lymphocyte antigen CD20; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1

Target 2

CD22

Gene ID

933

UniProt ID

P20273

Alternative Names

CD22; CD22 molecule; Cluster of differentiation 22; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2

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