Home > Products > CD20 & CD28 > Recombinant Anti-CD20 x Anti-CD28 Bispecific Antibody (Fab-VHH-Fc)

Recombinant Anti-CD20 x Anti-CD28 Bispecific Antibody (Fab-VHH-Fc)  (FABVC-363)

Recombinant Anti-CD20 x Anti-CD28 Bispecific Antibody (Fab-VHH-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CD20 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the VHH of anti-CD28 to the Fc-hole domain, or vice versa. The Fab-Fc and VHH-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can retarget T cells to tumor cells. It is designed for the research of Lymphoma therapy.

Specifications

Targets
CD20 & CD28
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
CD20
Host Animal 1
Mouse
Target 2
CD28
Host Animal 2
llama
Application
FuncS; Promising therapeutic agent
Related Disease
Lymphoma

Targets

Target 1
CD20
Gene ID
UniProt ID
Alternative Names
MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16; B-lymphocyte antigen CD20; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1
Target 2
CD28
Gene ID
UniProt ID
Alternative Names
CD28; CD28 molecule; Cluster of Differentiation 28; Tp44; T-cell-specific surface glycoprotein CD28; CD28 antigen

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Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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