Recombinant Anti-CD20 x Anti-CD28 Bispecific Antibody (Triple Body) (TRIB-050)

Recombinant Anti-CD20 x Anti-CD28 Bispecific Antibody (Triple Body) is designed to be expressed as two polypeptide chains respectively. The Fd fragment and LC from an anti-CD20 antibody are both extended with the scFv fragment from an anti-CD28 antibody. This BsAb can retarget T cells to tumor cells. It is designed for the research of Lymphoma therapy.

Datasheet

Specifications

Targets

CD20 & CD28

Type

Triple Body

Species Reactivity

Human

Target 1

CD20

Host Animal 1

Mouse

Target 2

CD28

Host Animal 2

Mouse

Application

FuncS; Promising therapeutic agent

Related Disease

Lymphoma

Targets

Target 1

CD20

Gene ID

931

UniProt ID

A0A024R507

Alternative Names

MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16; B-lymphocyte antigen CD20; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1

Target 2

CD28

Gene ID

940

UniProt ID

P10747

Alternative Names

CD28; CD28 molecule; Cluster of Differentiation 28; Tp44; T-cell-specific surface glycoprotein CD28; CD28 antigen

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