Home > Products > CD20 & CD3 > Recombinant Anti-CD20 x Anti-CD3 Bispecific Antibody (VHH-Fc-VHH)

Recombinant Anti-CD20 x Anti-CD3 Bispecific Antibody (VHH-Fc-VHH)  (HCAB-009)

Recombinant Anti-CD20 x Anti-CD3 Bispecific Antibody (VHH-Fc-VHH, Tetravalent HCAb) is a fusion protein of two diabodies connected together by an Fc region. In a diabody, the two VHHs with short linkers are from anti-CD20 and anti-CD3 antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to the Fc fragment, which results in 2+2 antigen-binding valency and exerts Fc-mediated functions or just extends the half-life. This BsAb can retarget T cells to tumor cells. It is designed for the research of Lymphoma therapy.

Specifications
Targets
CD20 & CD3
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
CD20
Host Animal 1
llama
Target 2
CD3
Host Animal 2
llama
Application
FuncS; Promising therapeutic agent
Related Disease
Lymphoma
Targets
Target 1
CD20
Gene ID
UniProt ID
Alternative Names
MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16; B-lymphocyte antigen CD20; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1
Target 2
CD3
Gene ID
UniProt ID
Alternative Names
CD47; CD47 molecule; IAP; OA3; MER6; leukocyte surface antigen CD47; CD47 glycoprotein; Rh-related antigen; integrin associated protein; integrin-associated protein; integrin-associated signal transducer; antigenic surface determinant protein OA3; antigen identified by monoclonal antibody 1D8; CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
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