Home > Products > CD20 & CD47 > Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (scFv-CH3)

Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (scFv-CH3)  (BSFC-052)

Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (scFv-CH3) contains two chains. The anti-CD20 scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-CD47 scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can retarget macrophages to tumor cells. It is designed for the research of Lymphoma therapy.

Specifications

Targets
CD20 & CD47
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
CD20
Host Animal 1
Mouse
Target 2
CD47
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Lymphoma

Targets

Target 1
CD20
Gene ID
UniProt ID
Alternative Names
MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16; B-lymphocyte antigen CD20; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1
Target 2
CD47
Gene ID
UniProt ID
Alternative Names
CD47; CD47 molecule; IAP; OA3; MER6; leukocyte surface antigen CD47; CD47 glycoprotein; Rh-related antigen; integrin associated protein; integrin-associated protein; integrin-associated signal transducer; antigenic surface determinant protein OA3; antigen identified by monoclonal antibody 1D8; CD47 antigen (Rh-related antigen, integrin-associated signal transducer)

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