Name: Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Tandem scFv-Fc)
SKU: BSFVF-052
Rating: 5 (1 reviews)

Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Tandem scFv-Fc) is designed to be expressed as a homodimer, which has 2+2 antigen-binding valency. This format consists of one Fc region and two tandem scFv fragments, in which the anti-CD20/CD47 tandem scFv is fused to the Fc domain. The engineered fragment format is used to extend the half-life. This BsAb can target CD20+ cells and block the CD47-SIRPα signal. It is designed for the research of Lymphoma therapy.

Datasheet INQUIRY

Specifications

Targets

CD20 & CD47

Type

Tandem scFv-Fc

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Lymphoma

Host Animal 1

Mouse

Host Animal 2

Mouse

Targets

Target 1

CD20

Gene ID

931

UniProt ID

A0A024R507

Alternative Names

MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16; B-lymphocyte antigen CD20; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1

Target 2

CD47

Gene ID

961

UniProt ID

Q08722

Alternative Names

CD47; CD47 molecule; IAP; OA3; MER6; leukocyte surface antigen CD47; CD47 glycoprotein; Rh-related antigen; integrin associated protein; integrin-associated protein; integrin-associated signal transducer; antigenic surface determinant protein OA3; antigen identified by monoclonal antibody 1D8; CD47 antigen (Rh-related antigen, integrin-associated signal transducer)

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Tandem scFv-Fc) (CAT#: BSFVF-052)

Specifications

Targets

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