Recombinant Anti-CD28 x Anti-CD3 Bispecific Antibody (Single-chain Diabody) (SCDB-H228)

Recombinant Anti-CD28 x Anti-CD3 Bispecific Antibody (Single-chain Diabody) is designed to be expressed as one polypeptide chain with four variable domains from two parental antibodies. The middle linker is long enough to form scFv dimers between the two diabody chains. This BsAb can improve T-cell activation. It is designed for the research of Tumors therapy.

Datasheet

Specifications

Targets

CD28 & CD3

Type

Single-chain Diabody

Species Reactivity

Human

Target 1

CD28

Host Animal 1

Human

Target 2

CD3

Host Animal 2

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Tumors

Targets

Target 1

CD28

Gene ID

940

UniProt ID

P10747

Alternative Names

CD28; CD28 molecule; Cluster of Differentiation 28; Tp44; T-cell-specific surface glycoprotein CD28; CD28 antigen

Target 2

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

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