Home > Products > CD28 & CD30 > Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (Fv-IgG)

Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (Fv-IgG)  (BSDG-055)

Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (Fv-IgG) is an appended IgG format, which has 2+2 antigen-binding valency. This dual variable domain IgG is generated by appending variable domains of an anti-CD28 IgG with similar domains from an anti-CD30 antibody via short peptide linkers, or vice versa. This BsAb can retarget T cells to tumor cells. It is designed for the research of Neuroblastoma; Osteosarcoma; Hodgkin lymphoma; T cell lymphoma; Anaplastic large cell lymphoma (ALCL) therapy.

Specifications

Targets
CD28 & CD30
Type
Appended IgGs
Species Reactivity
Human
Target 1
CD28
Host Animal 1
Mouse
Target 2
CD30
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Neuroblastoma; Osteosarcoma; Hodgkin lymphoma; T cell lymphoma; Anaplastic large cell lymphoma (ALCL)

Targets

Target 1
CD28
Gene ID
UniProt ID
Alternative Names
CD28; CD28 molecule; Cluster of Differentiation 28; Tp44; T-cell-specific surface glycoprotein CD28; CD28 antigen
Target 2
CD30
Gene ID
UniProt ID
Alternative Names
TNFRSF8; tumor necrosis factor receptor superfamily, member 8; CD30; Ki-1; D1S166E; tumor necrosis factor receptor superfamily member 8; Ki-1 antigen; CD30L receptor; cytokine receptor CD30; lymphocyte activation antigen CD30

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