Home > Products > CD28 & CD40 > Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (Diabody-Fc)

Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (Diabody-Fc)  (BSDBF-056)

Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (Diabody-Fc) is a fusion protein of two diabodies connected together by an Fc region. In a diabody, the two scFvs with short linkers are from anti-CD28 and anti-CD40 antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to the Fc fragment, which results in 2+2 antigen-binding valency and exerts Fc-mediated functions or just extends the half-life. This BsAb can increase T-cell proliferation, induce DC maturation and prime efficacy of cytotoxic T cells. It is designed for the research of Acute myeloid leukaemic (AML) therapy.

Specifications

Targets
CD28 & CD40
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
CD28
Host Animal 1
Mouse
Target 2
CD40
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Acute myeloid leukaemic (AML)

Targets

Target 1
CD28
Gene ID
UniProt ID
Alternative Names
CD28; CD28 molecule; Cluster of Differentiation 28; Tp44; T-cell-specific surface glycoprotein CD28; CD28 antigen
Target 2
CD40
Gene ID
UniProt ID
Alternative Names
CD40 molecule; CD40; p50; Bp50; Cluster of differentiation 40; CDW40; TNFRSF5; Tumor necrosis factor receptor superfamily member 5

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