Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (Fab-scFv-Fc) (FABVC-056)

Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CD28 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-CD40 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can increase T-cell proliferation, induce DC maturation and prime efficacy of cytotoxic T cells. It is designed for the research of Acute myeloid leukaemic (AML) therapy.

Datasheet INQUIRY

Specifications

Targets

CD28 & CD40

Type

Fab-Fc Fusion Proteins

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Acute myeloid leukaemic (AML)

Targets

Target 1

CD28

Gene ID

940

UniProt ID

P10747

Alternative Names

CD28; CD28 molecule; Cluster of Differentiation 28; Tp44; T-cell-specific surface glycoprotein CD28; CD28 antigen

Target 2

CD40

Gene ID

958

UniProt ID

P25942

Alternative Names

CD40 molecule; CD40; p50; Bp50; Cluster of differentiation 40; CDW40; TNFRSF5; Tumor necrosis factor receptor superfamily member 5

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (Fab-scFv-Fc) (CAT#: FABVC-056)

Specifications

Targets

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