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Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (Fab-scFv-Fc) (CAT#: FABVC-056)
Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CD28 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-CD40 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can increase T-cell proliferation, induce DC maturation and prime efficacy of cytotoxic T cells. It is designed for the research of Acute myeloid leukaemic (AML) therapy.
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