Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (Minibody) is designed to be expressed as the anti-CD28 scFv fused to N-terminus of Knob-CH3 domain and the anti-CD40 scFv to the Hole-CH3 domain, or vice versa. The CH3 domains are further stabilized by C-terminal disulfide bonds. This BsAb can increase T-cell proliferation, induce DC maturation and prime efficacy of cytotoxic T cells. It is designed for the research of Acute myeloid leukaemic (AML) therapy.
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