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Recombinant Human Anti-CD28 x Human Anti-CD40 Bispecific Antibody (scFv-Fc)  (BSCFV-H232)

Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (scFv-Fc) is formed by fusing two different scFv fragments to the hinge and Fc regions, in which the Fc region are engineered by KIH. Two of scFv moiety has the antibody variable domain of either anti-CD28 specificity or anti-CD40 specificity, which produces bivalent IgG-like molecules with desired characteristics of intact antibodies. This BsAb can increase T-cell proliferation, induce DC maturation and prime efficacy of cytotoxic T cells. It is designed for the research of Acute myeloid leukaemic (AML) therapy.

Specifications

Targets
CD28 & CD40
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
CD28
Host Animal 1
Mouse
Target 2
CD40
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Acute myeloid leukaemic (AML)

Targets

Target 1
CD28
Gene ID
UniProt ID
Alternative Names
CD28; CD28 molecule; Cluster of Differentiation 28; Tp44; T-cell-specific surface glycoprotein CD28; CD28 antigen
Target 2
CD40
Gene ID
UniProt ID
Alternative Names
CD40 molecule; CD40; p50; Bp50; Cluster of differentiation 40; CDW40; TNFRSF5; Tumor necrosis factor receptor superfamily member 5

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