Home > Products > CD28 & CD44 > Recombinant Human Anti-CD28 x Human Anti-CD44 Bispecific Antibody (Fab-scFv-Fc)

Recombinant Human Anti-CD28 x Human Anti-CD44 Bispecific Antibody (Fab-scFv-Fc)  (FABVC-H233)

Recombinant Anti-CD28 x Anti-CD44 Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CD28 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-CD44 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can retarget T cells to tumor cells. It is designed for the research of Glioblastoma; Squamous cancer therapy.

Specifications
Targets
CD28 & CD44
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
CD28
Host Animal 1
Human
Target 2
CD44
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Glioblastoma; Squamous cancer
Targets
Target 1
CD28
Gene ID
UniProt ID
Alternative Names
CD28; CD28 molecule; Cluster of Differentiation 28; Tp44; T-cell-specific surface glycoprotein CD28; CD28 antigen
Target 2
CD44
Gene ID
UniProt ID
Alternative Names
CD44; CD44 antigen; ECMRIII; Extracellular matrix receptor III; HCAM; Homing cell adhesion molecule; Pgp-1; phagocytic glycoprotein-1; HUTCH-1; Ly-24; Pgp-1; HERMES; AU023126; AW121933; AW146109
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