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Recombinant Anti-CD28 x Anti-EGFR Bispecific Antibody (scFv-CH3) (CAT#: BSFC-058)
Recombinant Anti-CD28 x Anti-EGFR Bispecific Antibody (scFv-CH3) contains two chains. The anti-CD28 scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-EGFR scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can retarget T cells to tumor cells. It is designed for the research of Head and neck cancer; Colorectal cancer (CRC); Glioblastoma multiforme (GBM); Squamous cancer; Glioblastoma; Medulloblastoma; Non-small cell lung cancer (NSCLC); Renal cell cancer (RCC); Solid tumors therapy.
Head and neck cancer; Colorectal cancer (CRC); Glioblastoma multiforme (GBM); Squamous cancer; Glioblastoma; Medulloblastoma; Non-small cell lung cancer (NSCLC); Renal cell cancer (RCC); Solid tumors
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