Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Minibody) is designed to be expressed as the anti-CD28 scFv fused to N-terminus of Knob-CH3 domain and the anti-EPCAM scFv to the Hole-CH3 domain, or vice versa. The CH3 domains are further stabilized by C-terminal disulfide bonds. This BsAb can retarget T cells to tumor cells. It is designed for the research of Melanoma; Glioblastoma multiforme (GBM); Non-small cell lung (NSCLC); Colorectal cancer (CRC); Solid tumors therapy.
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