Home > Products > CD28 & EPCAM > Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (scFv-CH3)

Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (scFv-CH3)  (BSFC-059)

Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (scFv-CH3) contains two chains. The anti-CD28 scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-EPCAM scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can retarget T cells to tumor cells. It is designed for the research of Melanoma; Glioblastoma multiforme (GBM); Non-small cell lung (NSCLC); Colorectal cancer (CRC); Solid tumors therapy.

Specifications
Targets
CD28 & EPCAM
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
CD28
Host Animal 1
Mouse
Target 2
EPCAM
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Melanoma; Glioblastoma multiforme (GBM); Non-small cell lung (NSCLC); Colorectal cancer (CRC); Solid tumors
Targets
Target 1
CD28
Gene ID
UniProt ID
Alternative Names
CD28; CD28 molecule; Cluster of Differentiation 28; Tp44; T-cell-specific surface glycoprotein CD28; CD28 antigen
Target 2
EPCAM
Gene ID
UniProt ID
Alternative Names
EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1; epithelial glycoprotein 314; human epithelial glycoprotein-2; cell surface glycoprotein Trop-1; adenocarcinoma-associated antigen; tumor-associated calcium signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; membrane component, chromosome 4, surface marker (35kD glycoprotein)
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