Home > Products > CD28 & FOLR1 > Recombinant Anti-CD28 x Anti-FOLR1 Bispecific Antibody (scFv-Fc)

Recombinant Anti-CD28 x Anti-FOLR1 Bispecific Antibody (scFv-Fc)  (BSCFV-060)

Recombinant Anti-CD28 x Anti-FOLR1 Bispecific Antibody (scFv-Fc) is formed by fusing two different scFv fragments to the hinge and Fc regions, in which the Fc region are engineered by KIH. Two of scFv moiety has the antibody variable domain of either anti-CD28 specificity or anti-FOLR1 specificity, which produces bivalent IgG-like molecules with desired characteristics of intact antibodies. This BsAb can retarget T cells to tumor cells. It is designed for the research of Ovarian cancer; Solid tumors therapy.

Specifications
Targets
CD28 & FOLR1
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
CD28
Host Animal 1
Mouse
Target 2
FOLR1
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Ovarian cancer; Solid tumors
Targets
Target 1
CD28
Gene ID
UniProt ID
Alternative Names
CD28; CD28 molecule; Cluster of Differentiation 28; Tp44; T-cell-specific surface glycoprotein CD28; CD28 antigen
Target 2
FOLR1
Gene ID
UniProt ID
Alternative Names
FOLR1; folate receptor 1 (adult); folate receptor 1; FBP; FOLR; folate receptor alpha; FR-alpha; KB cells FBP; folate binding protein; folate receptor, adult; adult folate-binding protein; ovarian tumor-associated antigen MOv18
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