Home > Products > CD28 & HN > Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (Fab-scFv-Fc)

Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (Fab-scFv-Fc)  (FABVC-H237)

Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CD28 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-HN to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can retarget T cells to tumor cells. It is designed for the tumor vaccine modification and the research of Tumors therapy.

Specifications
Targets
CD28 & HN
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
CD28
Host Animal 1
Human
Target 2
HN
Host Animal 2
Human
Application
FuncS; Promising preventive/therapeutic agent
Related Disease
Tumors
Targets
Target 1
CD28
Gene ID
UniProt ID
Alternative Names
CD28; CD28 molecule; Cluster of Differentiation 28; Tp44; T-cell-specific surface glycoprotein CD28; CD28 antigen
Target 2
HN
Gene ID
UniProt ID
Alternative Names
Hemagglutinin-neuraminidase; HN

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