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Recombinant Anti-CD28 x Anti-MUC1 Bispecific Antibody (IgG(L)-scFv)  (IGLFV-062)

Recombinant Anti-CD28 x Anti-MUC1 Bispecific Antibody (IgG(L)-scFv) is formed by an IgG and two scFv moieties. The scFv fragments from an anti-CD28 antibody are fused to the C terminus of an anti-MUC1 IgG light (L) chains, or vice versa. It is a type of appended IgGs, which is bispecific and tetravalent (2+2 antigen-binding valency). This BsAb can retarget T cells to tumor cells. It is designed for the research of Pancreatic cancer; Ovarian cancer; Breast cancer; Bile duct cancer (BDC) therapy.

Specifications

Targets
CD28 & MUC1
Type
Appended IgGs
Species Reactivity
Human
Target 1
CD28
Host Animal 1
Mouse
Target 2
MUC1
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Pancreatic cancer; Ovarian cancer; Breast cancer; Bile duct cancer (BDC)

Targets

Target 1
CD28
Gene ID
UniProt ID
Alternative Names
CD28; CD28 molecule; Cluster of Differentiation 28; Tp44; T-cell-specific surface glycoprotein CD28; CD28 antigen
Target 2
MUC1
Gene ID
UniProt ID
Alternative Names
MUC1; mucin 1, cell surface associated; EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; mucin-1; episialin; DF3 antigen; H23 antigen; cancer antigen 15-3; krebs von den Lungen-6; mucin 1, transmembrane; carcinoma-associated mucin; polymorphic epithelial mucin; peanut-reactive urinary mucin; tumor associated epithelial mucin; breast carcinoma-associated antigen DF3; tumor-associated epithelial membrane antigen; Medullary cystic kidney disease, autosomal dominant

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