Recombinant Anti-CD3 x Anti-CD248 Bispecific Antibody (Minibody) (MiniB-078)

Recombinant Anti-CD3 x Anti-CD248 Bispecific Antibody (Minibody) is designed to be expressed as the anti-CD3 scFv fused to N-terminus of Knob-CH3 domain and the anti-CD248 scFv to the Hole-CH3 domain, or vice versa. The CH3 domains are further stabilized by C-terminal disulfide bonds. This BsAb can retarget T cells to tumor cells. It is designed for the research of Solid tumors therapy.

Datasheet

Specifications

Targets

CD3 & CD248

Type

Minibody

Species Reactivity

Human

Target 1

CD3

Host Animal 1

Mouse

Target 2

CD248

Host Animal 2

Mouse

Application

FuncS; Promising therapeutic agent

Related Disease

Solid tumors

Targets

Target 1

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

Target 2

CD248

Gene ID

57124

UniProt ID

Q9HCU0

Alternative Names

CD248; CD248 molecule, endosialin; TEM1; CD164L1; endosialin; 2610111G01Rik; CD164 sialomucin-like 1; CD248 antigen, endosialin; tumor endothelial marker 1

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