Recombinant Anti-CD3 x Anti-CD248 Bispecific Antibody (VHH-Fc-VHH) (HCAB-021)

Recombinant Anti-CD3 x Anti-CD248 Bispecific Antibody (VHH-Fc-VHH, Tetravalent HCAb) is a fusion protein of two diabodies connected together by an Fc region. In a diabody, the two VHHs with short linkers are from anti-CD3 and anti-CD248 antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to the Fc fragment, which results in 2+2 antigen-binding valency and exerts Fc-mediated functions or just extends the half-life. This BsAb can retarget T cells to tumor cells. It is designed for the research of Solid tumors therapy.

Datasheet INQUIRY

Specifications

Targets

CD3 & CD248

Type

Constant Domain-extended Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Epithelial cancers

Targets

Target 1

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

Target 2

CD248

Gene ID

2191

UniProt ID

B4DLR2

Alternative Names

FAP; fibroblast activation protein, alpha; FAPA; SIMP; Fibroblast activation protein; DPPIV; prolyl endopeptidase FAP; seprase; FAPalpha; dipeptidyl peptidase FAP; surface-expressed protease; post-proline cleaving enzyme; gelatine degradation protease FAP; F19 cell surface antigen; integral membrane serine protease; serine integral membrane protease; 170 kDa melanoma membrane-bound gelatinase

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-CD3 x Anti-CD248 Bispecific Antibody (VHH-Fc-VHH) (CAT#: HCAB-021)

Specifications

Targets

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