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Recombinant Human Anti-CD3 x Human Anti-CD30 Bispecific Antibody (scFv-Fc)  (BSCFV-H241)

Recombinant Anti-CD3 x Anti-CD30 Bispecific Antibody (scFv-Fc) is formed by fusing two different scFv fragments to the hinge and Fc regions, in which the Fc region are engineered by KIH. Two of scFv moiety has the antibody variable domain of either anti-CD3 specificity or anti-CD30 specificity, which produces bivalent IgG-like molecules with desired characteristics of intact antibodies. This BsAb can retarget T cells to tumor cells. It is designed for the research of Neuroblastoma; Osteosarcoma; Hodgkin lymphoma; T cell lymphoma; Anaplastic large cell lymphoma (ALCL) therapy.

Specifications

Targets
CD3 & CD30
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
CD3
Host Animal 1
Mouse
Target 2
CD30
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Neuroblastoma; Osteosarcoma; Hodgkin lymphoma; T cell lymphoma; Anaplastic large cell lymphoma (ALCL)

Targets

Target 1
CD3
Gene ID
UniProt ID
Alternative Names
CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
Target 2
CD30
Gene ID
UniProt ID
Alternative Names
CD30; TNFRSF8; tumor necrosis factor receptor superfamily member 8; TNF receptor superfamily member 8; CD30; Ki-1; D1S166E

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